What Is Epilepsy?
Epilepsy is a chronic disorder characterized by recurrent and unprovoked seizures. Having seizures and epilepsy can affect one's safety, relationships, work, driving and so much more.
The Human brain is the source of epilepsy, although the symptoms of a seizure may affect any part of the body. While the location of the initial epileptic event occurs in the brain, how it spreads and how much of the brain is affected determines the effects on the rest of the body. These factors determine the character of a seizure and its impact on the individual. For the reason Epilepsy has many symptoms and it is largely viewed that no two epilepsy's are alike.
For more information about epilepsy please look to the following websites.
Our Drug Pipeline
OB Pharmaceuticals has developed a new class of compounds (oxynytones) that act at a unique target in the brain to prevent electrical activity that leads to seizures. Our compounds not only stop seizures from occurring in epileptic brains but also prevent epilepsy from occurring in the first place. This activity combined with low or no side effects makes oxynytones one of the most promising new preclinical medications currently under development.
Epilepsy Research Publications
Neurobiology of Disease
The loss of interneuron functional diversity in the piriform cortex after induction of experimental epilepsy
Interneuronal functional diversity is thought to be an important factor in the control of neural network oscillations in many brain regions. Specifically, interneuron action potential firing patterns are thought to modulate brain rhythms. In neurological disorders such as epilepsy where brain rhythms are significantly disturbed interneuron function is largely unexplored. Thus the purpose of this study was to examine the functional diversity of piriform cortex interneurons (PC; an area of the brain that easily supports seizures) before and after kindling-induced epilepsy. Using cluster analysis, we found five control firing behaviors. These groups were termed: non-adapting very high frequency (NAvHF), adapting high frequency (AHF), adapting low frequency (ALF), strongly adapting low frequency (sALF), and weakly adapting low frequency (wALF).
Frontiers in Neural Circuits
Zeinab Birjandian , Chakravarthi Narla and Michael O. Poulter
The inhibition of excitatory (pyramidal) neurons directly dampens their activity resulting in a suppression of neural network output. The inhibition of inhibitory cells is more complex. Inhibitory drive is known to gate neural network synchrony, but there is also a widely held view that it may augment excitability by reducing inhibitory cell activity, a process termed disinhibition. Surprisingly, however, disinhibition has never been demonstrated to be an important mechanism that augments or drives the activity of excitatory neurons in a functioning neural circuit. Using voltage sensitive dye imaging (VSDI) we show that 20–80 Hz stimulus trains, β–γ activation, of the olfactory cortex pyramidal cells in layer II leads to a subsequent reduction in inhibitory interneuron activity that augments the efficacy of the initial stimulus